milk thistle depression
Store at room temperature away from moisture, heat, and light. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. . Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Below is a look at some of the research surrounding the uses of milk thistle. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). But experts say that the evidence isnt conclusive. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Reflux Risk and Relief View More . Large-scale, properly-designed studies are needed. You may report side effects to FDA at 1-800-FDA-1088. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. Elsevier; 2021. https://www.clinicalkey.com. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. A double-blind controlled study. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver. Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Some people are advised to be cautious when taking milk thistle. But studies on heart benefits have only been done in people with diabetes. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. See additional information. ; Extensively studied; effective in treatment of cirrhosis, hepatitis, chemical- or . Is There a Reason Your Milk Thistle Isn't Working? We comply with the HONcode standard for trustworthy health information. After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. https://www.micromedexsolutions.com. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Disclaimer. Available for Android and iOS devices. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. This content does not have an Arabic version. Silymarin: not just another antioxidant. It is native to Mediterranean countries. People may also find it painful and worry about its effects on their appearance. As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Ask your doctor for advice. Some people may be allergic to milk thistle. The .gov means its official. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). Milk thistle is promoted as a dietary supplement for . Seeff, L.; Curto, T.; Szabo, G. et al. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Natural Medicines website. If we combine this information with your protected Theres conflicting research on the benefits of milk thistle for liver health. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. Combining silybin with phosphatidylcholine and other phospholipids enhances the absorption of milk thistle's active compounds, providing powerful liver health support. Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Nat Neurosci. Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. World J Gastroenterol. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Camini FC, Costa DC. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Milk thistle is generally considered safe when taken by mouth (1, 45). Phytother Res. But even if youve figured out how to manage the symptoms and compulsions, the side effects of many FDA-approved OCD medications can introduce a wide swath of issues and side effects. Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). Consult with a licensed healthcare professional before using any herbal/health supplement. However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). Side effects are always possible when taking supplements. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; This is not a complete list of side effects and others may occur. Verywell Health's content is for informational and educational purposes only. By using our site, you acknowledge that you have read and understand our. Please enable it to take advantage of the complete set of features! There is a problem with National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Read our. 2014;97 Suppl 11:S31-S40. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk thistle is sold as an oral capsule, tablet and liquid extract. The terms "milk thistle" and "silymarin" are often used interchangeably. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. Review/update the Milk thistle (Silybum marianum) is a plant traditionally used as a liver tonic. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It is possibly effective in diabetes and indigestion (). Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Effects of Silybum marianum (L.) Gaertn. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. What Is Complementary, Alternative, or Integrative Health? It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. People have traditionally used milk thistle for problems with the liver and gallbladder . Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Do not give any herbal/health supplement to a child without medical advice. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. 2023 May;475(5):621-635. doi: 10.1007/s00424-023-02795-y. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Clipboard, Search History, and several other advanced features are temporarily unavailable. information and will only use or disclose that information as set forth in our notice of 2016;68(4):1026-1073. doi:10.1124/pr.115.010843. Bookshelf Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Website: https://pubmed.ncbi.nlm.nih.gov/. PMC The therapeutic potential of milk thistle in diabetes. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. N-Acetylcysteine Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. This content does not have an English version. Milk thistle (PDQ): Health Professional Version. Epub 2019 Nov 24. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. National Center for Complementary and Integrative Health. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Depression and anxiety are associated with increased risk of developing AD. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. Advertising revenue supports our not-for-profit mission. Keywords: Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. When considering the use of herbal supplements, seek the advice of your doctor. Unexpected effects from milk thistle. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). official website and that any information you provide is encrypted Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Healthline Media does not provide medical advice, diagnosis, or treatment. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. Do not use this product without medical advice if you are pregnant. National Center for Complementary and Integrative Health. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Written by Cerner Multum. Accessed Oct. 30, 2020. Risks. Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. The nutritional content varies for each brand, so be sure to . 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Scan J Gastroenterol. Learn more about natural remedies for type 2 diabetes. 2023 Natural Wellness. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. This publication is not copyrighted and is in the public domain. Milk thistle. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. In: Textbook of Natural Medicine. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. One human trial found it to work as well as fluoxetine to manage OCD symptoms. Multiple Myeloma vs. Leukemia: What Are the Differences? Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. This makes it very hard to establish a standard dose. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. 2016;5147468. doi:10.1155/2016/5147468. FOIA Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. HHS Vulnerability Disclosure, Help Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Its been discovered that one of the compounds in milk thistle may work similarly to some diabetic medications by helping improve insulin sensitivity and decrease blood sugar (43). Biomed Pharmacother. However, there is no solid evidence that supports these claims. 5th ed. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. It is not certain whether milk thistle is effective in treating any medical condition. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. 2023 Healthline Media LLC. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. 2018;8:65-74. doi:10.2147/PTT.S169333. Pizzorono JE, et al., eds. Therefore, it may be best to avoid milk thistle during these life stages. Milk thistle is a plant named for the white veins on its large prickly leaves. Do not use this product without medical advice if you are breast-feeding a baby. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. #1: Milk thistle detoxifies the liver. However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. However, research is not conclusive on its uses. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Adv Ther. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Side effects. Depression, Milk Thistle, Mood, Silibum Marianum (milk thistle), Silymarin. However, as this is the only study, more high-quality research is needed. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. Can You Get Milk Thistle Naturally From Foods? BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. 2018;9:1903. doi:10.3389/fimmu.2018.01903, Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. However, the evidence is conflicting. There's limited evidence, though, for the role of milk thistle in bone health. If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. The https:// ensures that you are connecting to the Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Unable to load your collection due to an error, Unable to load your delegates due to an error. Although rare, milk thistle may trigger a number of common and mild side effects. However, there are currently no human studies, so its effectiveness remains unclear. Front Immunol. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Some people have nausea, diarrhea, itching, and bloating. Call your doctor for medical advice about side effects. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Milk thistle is not recommended for children. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. It is not known whether milk thistle will harm an unborn baby. Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. Am J Gastroenterol. Accessed Oct. 30, 2020. . One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Do not use more of this product than is recommended on the label. While milk thistle is considered a noxious weed in various parts of the United States, it has little oral consumption value and is best absorbed in tablet or capsule supplement form, but can also be consumed as a tea or oral tincture. To ensure quality and potency in your herbal remedies, why not grow your own? Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). Bookmark the permalink. Milk thistle is primarily taken in supplements sold as tablets, capsules, or extract primarily to help with liver function. Its thought to work by making more of the milk-producing hormone prolactin. Do not use extra milk thistle to make up the missed dose. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. An official website of the United States government. Generic name: milk thistle [MILK-THIH-sull] the unsubscribe link in the e-mail. While not dangerous, it can cause scars. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010, Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. There are no other food sources of this herb. However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Silymarin is believed to have antioxidant properties. Learn. 1982;17:51721. Click here for an email preview. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding.